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World Sepsis Day 2023

 Your donation to ISID is a contribution that supports the urgent need to increase and improve health education and literacy at every level in the fight against sepsis.

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World Sepsis Day is an initiative established in 2012 by the Global Sepsis Alliance and is an opportunity to increase public awareness of this disease. Sepsis is a life-threatening condition that arises when the body’s response to an infection causes injury to its own tissues and organs. It may lead to shock, multiple organ failure, and death, especially if not recognized early and treated promptly. Additionally, despite being highly preventable, for example, maternal and neonatal cases of sepsis continue to be a major cause of death for pregnant women and newborn babies.

The World Health Assembly and the World Health Organization made sepsis a global health priority in 2017. This year, the Berlin Declaration on Sepsis will call for its urgent enforcement at the national level. Global reinvigorated actions, highlighting the need for urgent advances in programmatic implementation,  strengthening health systems, and health literacy interventions are crucial. The impact of innovations in the field of prevention, diagnosis, and treatment of infections and sepsis is needed as well.

Join ISID on this commemoration as a great reminder that the urgent need to increase and improve health education and literacy stands at every level.

You can also read related and recent publications in our ISID public health journals below, as well as our recent ISID Knowledge Exchange open-access webinar:

Speakers:

  • Nesrine Rizk, Lebanon
    • Sepsis Management Challenges
  •  Imad Bou Akl, Lebanon
    • Sepsis Management Guideline Update

Chair: ISID Executive Committee Member, Jaffar Al-Tawfiq, Saudi Arabia
Co-Chair: ISID Emerging Leader, Vrinda Nampoothiri, India

Sepsis is the body’s extreme response to an infection. Despite recent progress in the understanding and treatment of sepsis, few data or recommendations exist that detail effective approaches to sepsis care in resource-limited low-income and middle-income countries. Although few data exist on the burden of sepsis in LMICs, the prevalence of HIV and other comorbid conditions in some LMICs suggest that sepsis is a substantial contributor to mortality in these regions. In well-resourced countries, sepsis management relies on protocols and complex invasive technologies not widely available in most LMICs. However, key concepts and components of sepsis management are potentially translatable to resource-limited environments. Health personnel in LMICs should learn how to recognize sepsis and the importance of early and appropriate antibiotic use and laboratory diagnosis of sepsis. Simple and low-cost standardized laboratory testing should be emphasized to allow accurate diagnosis, prognosis, and monitoring of treatment response. Evidence-based interventions and treatment algorithms tailored to LMIC ecology and resources should thus be developed and validated.

*This webinar is supported by an unrestricted educational grant from bioMérieux.

International Journal of Infectious Diseases (IJID)

Effectiveness of intravenous immunoglobulin therapy for invasive group A Streptococcus infection: A Japanese nationwide observational study

Atsushi Senda, Akira Endo, Kiyohide Fushimi, Yasuhiro Otomo. Effectiveness of intravenous immunoglobulin therapy for invasive group A Streptococcus infection: A Japanese nationwide observational study. International Journal of Infectious Diseases (2023). DOI: https://doi.org/10.1016/j.ijid.2023.08.011

Staphylococcus epidermidis bloodstream infections are a cause of septic shock in intensive care unit patients

Julien Demiselle, Pierre Meyer, Thierry Lavigne, Julian Kaurin, Hamid Merdji, Maleka Schenck, Antoine Studer, Ralf Janssen-Langenstein, Julie Helms, Baptiste Hoellinger, Vincent Castelain, Antoine Grillon, Francis Schneider, Ferhat Meziani, Raphaël Clere-Jehl, Clinical Research in Intensive Care and Sepsis - TRIal Group for Global Evaluation and Research in SEPsis (CRICS-TRIGGERSEP). International Journal of Infectious Diseases (2023). DOI: https://doi.org/10.1016/j.ijid.2023.07.014

Carbapenem-sparing beta-lactam/beta-lactamase inhibitors versus carbapenems for bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a systematic review and meta-analysis

Huan Zhang, Juan Xu, Qinyan Xiao, Yuhang Wang, Jin Wang, Man Zhu, Yun Cai. Carbapenem-sparing beta-lactam/beta-lactamase inhibitors versus carbapenems for bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a systematic review and meta-analysis. International Journal of Infectious Diseases (2023). DOI: https://doi.org/10.1016/j.ijid.2023.01.001

The efficacy and safety of a shortened duration of antimicrobial therapy for group A Streptococcus bacteremia

Andrew D.K. Nguyen, Simon Smith, Tania J. Davis, Trent Yarwood, Josh Hanson. The efficacy and safety of a shortened duration of antimicrobial therapy for group A Streptococcus bacteremia. International Journal of Infectious Diseases (2023). DOI: https://doi.org/10.1016/j.ijid.2022.12.015

IJID Regions

Retrospective analysis of bacteraemia due to extended-spectrum beta-lactamase-producing Enterobacterales: the challenge of healthcare-associated infections

Anna Maria Peri, Davide Calabretta, Giorgio Bozzi, Guglielmo Marco Migliorino, Simone Bramati, Andrea Gori, Alessandra Bandera. Retrospective analysis of bacteraemia due to extended-spectrum beta-lactamase-producing Enterobacterales: the challenge of healthcare-associated infections. IJID Regions (2023). DOI: https://doi.org/10.1016/j.ijregi.2023.01.005

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